Identification of dihydropyridines that reduce cellular tau levels.

نویسندگان

  • Christopher G Evans
  • Umesh K Jinwal
  • Leah N Makley
  • Chad A Dickey
  • Jason E Gestwicki
چکیده

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.

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عنوان ژورنال:
  • Chemical communications

دوره 47 1  شماره 

صفحات  -

تاریخ انتشار 2011